Science Behind Our Kit
Our innovative in-house algorithm employs supervised learning to calculate biological age by harnessing a comprehensive array of genomic, proteomic, functional, and clinical biomarkers. These biomarkers collectively influence various aging hallmarks, ensuring a thorough assessment of the aging process.
Hallmarks of aging
Genomic instability
Damage to DNA leading to mutations and cellular dysfunction.
Telomere attrition
Shortening the protective caps on chromosomes is associated with cell aging.
Epigenetic alterations
Changes in gene expression patterns without alterations to DNA sequence.
Loss of proteostasis
Decline in cell's ability to maintain protein structure and function.
Disabled Macroautophagy
When damaged organelles and proteins aren't cleared properly, leading to cellular dysfunction.
De-regulated nutrient sensing
Disruption in cellular response to nutrient levels, affecting metabolism.
Mitochondrial dysfunction
Impaired energy production and increased oxidative stress due to dysfunctional mitochondria.
Cellular Senescence
Permanent growth arrest in cells contributes to tissue aging and dysfunction.
Stem cell exhaustion
Reduced ability of stem cells to regenerate tissues and organs.
Altered intercellular communication
Dysfunctional signaling between cells, impacting tissue homeostasis.
Chronic Inflammation
Persistent, low-grade bodily inflammation often due to an overactive immune response, contributing to various diseases.
Dysbiosis
Imbalance in gut microbes, impacting health.
Our Approach
How do we analyze and determine your Biological Age?
Our innovative in-house algorithm employs supervised learning to calculate biological age by harnessing a comprehensive array of genomic, proteomic, functional, and clinical biomarkers. These biomarkers collectively influence various aging hallmarks, ensuring a thorough assessment of the aging process.
Understand your report
Your Report will include:
- What we do?
- What is Biological age?
- Genomic Markers
- Proteomic Markers
- Functional and clinical markers
- Insights, suggestions & Recommendations
- Citations
Enhance your health-span and extend your longevity
- Based on the data and algorithm and the results obtained, our physicians and dieticians shall formulate a recommended program of wellness and lifestyle management.
- You can program work-life balance, exercise, nutrition
- Frequent measurement of your biological age will act as a compass for tracking your health.
References and Literature
Key Aging Related Research Publications by our Founder
- Suresh Poosala, Jacob M Zahn (both first authors), et al., AGEMAP: Comparison of aging expression profiles in diverse and common patterns of aging in mice and humans. PLoS Genetics, 2007;3(11).
- Poosala Suresh, et al., Age-related changes of Claudin expression in mouse liver, kidney and pancreas. The Journal of Gerontology.2009; 64(11):1146-53.
- Poosala S, et al., Nrf2 mediates cancer protection but not longevity induced by caloric restriction. ProcNatlAcadSciUSA.2008;105(7):2325-2330.